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You are here: Home / CONFERENCE / Keynote Speaker: Dale L. Boger, Ph.D.

Keynote Speaker: Dale L. Boger, Ph.D.

January 25, 2017 by wpdev

 

Richard and Alice Cramer Professor and Chairman of Department of Chemistry, The Scripps Research Institute (California Campus)

Dale Boger received his B.Sc. in chemistry from the University of Kansas, Lawrence, Kansas (1975, with highest distinction and honors in chemistry) and Ph.D. in chemistry from Harvard University (1980) under the direction of E. J. Corey. He returned to the University of Kansas as a member of the faculty in the Department of Medicinal Chemistry (1979-1985), moved to the Department of Chemistry at Purdue University (1985-1990), and joined the faculty in the newly created Department of Chemistry at The Scripps Research Institute (1990-present) as the Richard and Alice Cramer Professor of Chemistry. Since 2012, he has served as the Chairman for the Department of Chemistry. Professor Boger is internationally recognized for his work in organic synthesis, heterocyclic chemistry, natural products total synthesis and mechanistic studies on their biological activity, synthetic methodology development, and medicinal chemistry. He has made seminal contributions to the understanding of DNA-agent interactions of naturally occurring antitumor-antibiotics, protein-protein interactions, and to the discovery of new biological targets (e.g. FAAH). Most notable are his development and application of the hetero Diels-Alder reaction to the syntheses of complex natural products, his development and applications of the cycloaddition reactions of cyclopropenone ketals, methodology based on the alkene addition reactions of acyl radicals, medium and large ring macrocyclization technology, and solution phase combinatorial chemistry methodology. Beautiful applications of this may be found in his total syntheses of natural products including bleomycin A2, CC-1065, yatakemycin, streptonigrin, lavendamycin, colchicine, vancomycin, teicoplanin, ristocetin, chloropeptin, vinblastine and vincristine, vindoline and vindorosine, prodigiosin, roseophilin, chlorofusin, duocarmycin A and SA, fostriecin, cytostatin, phostriecin, fredericamycin A, streptonigrone, bouvardin, sandramycin, luzopeptins A–C, quinoxapeptins A–C, thiocoraline, HUN-7293, isochrysohermidin, mappicine, camptothecin, piericidins, ningalins, phomazarin, rubrolone, and grandirubrine. Many of the above compounds were addressed because of their biological properties. For example, Professor Boger’s group was not only the first to prepare duocarmycin SA and more recently yatakemycin, but they went on to define their DNA alkylation properties. In these studies they made the unusual observation that both enantiomers of the natural product constitute effective DNA alkylating agents, have identified a remarkable source of catalysis for the DNA alkylation reaction, and have defined subtle structural and stereoelectronic features of the agents that contribute to functional reactivity and reaction regioselectivity and their impact on the DNA alkylation and biological properties. Similarly, his group was the first to extend their total synthesis of the glycopeptides antibiotics to redesigned vancomycin structures to address vancomycin resistance.

Honors:

1975-78           NSF Predoctoral Fellowship

1981-85           Searle Scholar Recipient

1983-88           NIH Research Career Development Award

1985-87           Alfred P. Sloan Fellowship

1988                ACS A. C. Cope Scholar

1989                American Cyanamid Academic Award

1997                ISHC Katritzky Award in Heterocyclic Chemistry

1999                ACS Aldrich Award for Creativity in Organic Synthesis

2002                Paul Janssen Prize for Creativity in Organic Synthesis

2003                Royal Society of Chemistry Adrien Albert Medal

2003                Fellow, American Association for the Advancement of Science

2006                Elected to American Academy of Arts and Sciences

2007                ACS Guenther Award in the Chemistry of Natural Products

2009                Fellow, Royal Society of Chemistry

2010                Fellow, American Chemical Society

2011                ACS Portoghese Prize Lecturer

2013                ACS Hirschmann Award in Peptide Chemistry

2014                AACR Award for Outstanding Chemistry in Cancer Research

2014                Elected to US National Academy of Sciences

2016                Elected to National Academy of Inventors

Editor: 1990-2015    Bioorganic and Medicinal Chemistry Letters (founding editor)

 

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